Imbalance between endothelial damage and repair capacity in chronic obstructive pulmonary disease.

ABSTRACT:

Background

Circulating endothelial microparticles (EMPs) and progenitor cells (PCs) are biological markers of endothelial function and endogenous repair capacity. The study was aimed to investigate whether COPD patients have an imbalance between EMPs to PCs compared to controls and to evaluate the effect of cigarette smoke on these circulating markers.

Methods

Circulating EMPs and PCs were determined by flow cytometry in 27 nonsmokers, 20 smokers and 61 COPD patients with moderate to severe airflow obstruction. We compared total EMPs (CD31+CD42b-), apoptotic if they co-expressed Annexin-V+ or activated if they co-expressed CD62E+, circulating PCs (CD34+CD133+CD45+) and the EMPs/PCs ratio between groups.

Results

COPD patients presented increased levels of total and apo

SUBMITTER: Garcia-Lucio J 

PROVIDER: S-EPMC5908268 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature