Canonical NF-κB signaling in myeloid cells promotes lung metastasis in a mouse breast cancer model.

ABSTRACT: An inflammatory tumor microenvironment is a common characteristic of solid tumors. It is the result of a complex interplay between tumor cells, tumor infiltrating immune cells and other stromal cells. Myeloid cells in the tumor microenvironment are considered major drivers of tumor progression and metastasis and increased numbers of these cells are associated with poor prognosis in various cancer patients. The transcription factor NF-κB is considered the master regulator of inflammatory gene expression and immune cell function. Its activation in various cells of the tumor microenvironment contributes essentially to tumorigenesis. In the present study, the role of canonical NF-κB signaling in myeloid cells in metastatic breast cancer was addressed by myeloid-specific deletion of Ikkβ

SUBMITTER: Neumann T 

PROVIDER: S-EPMC5908285 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature