Ontology highlight
ABSTRACT:
SUBMITTER: Czardybon W
PROVIDER: S-EPMC5908295 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Czardybon Wojciech W Windak Renata R Gołas Aniela A Gałęzowski Michał M Sabiniarz Aleksandra A Dolata Izabela I Salwińska Magdalena M Guzik Paweł P Zawadzka Magdalena M Gabor-Worwa Ewelina E Winnik Bożena B Żurawska Małgorzata M Kolasińska Ewa E Wincza Ewelina E Bugaj Marta M Danielewicz Monika M Majewska Eliza E Mazan Milena M Dubin Grzegorz G Noyszewska-Kania Monika M Jabłońska Ewa E Szydłowski Maciej M Sewastianik Tomasz T Puła Bartosz B Szumera-Ciećkiewicz Anna A Prochorec-Sobieszek Monika M Mądro Elżbieta E Lech-Marańda Ewa E Warzocha Krzysztof K Tamburini Jerome J Juszczyński Przemysław P Brzózka Krzysztof K
Oncotarget 20180330 24
Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) is one of the most common genetic lesions in acute myeloid leukemia patients (AML). Although FLT3 tyrosine kinase inhibitors initially exhibit clinical activity, resistance to treatment inevitably occurs within months. PIM kinases are thought to be major drivers of the resistance phenotype and their inhibition in relapsed samples restores cell sensitivity to FLT3 inhibitors. Thus, simultaneous PIM and FLT3 inhibition represents a ...[more]