A Micropatterned Multielectrode Shell for 3D Spatiotemporal Recording from Live Cells.

ABSTRACT: Microelectrode arrays (MEAs) have proved to be useful tools for characterizing electrically active cells such as cardiomyocytes and neurons. While there exist a number of integrated electronic chips for recording from small populations or even single cells, they rely primarily on the interface between the cells and 2D flat electrodes. Here, an approach that utilizes residual stress-based self-folding to create individually addressable multielectrode interfaces that wrap around the cell in 3D and function as an electrical shell-like recording device is described. These devices are optically transparent, allowing for simultaneous fluorescence imaging. Cell viability is maintained during and after electrode wrapping around the cel and chemicals can diffuse into and out of the self-folding dev

SUBMITTER: Cools J 

PROVIDER: S-EPMC5908352 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature