A comprehensive and quantitative exploration of thousands of viral genomes.

ABSTRACT: The complete assembly of viral genomes from metagenomic datasets (short genomic sequences gathered from environmental samples) has proven to be challenging, so there are significant blind spots when we view viral genomes through the lens of metagenomics. One approach to overcoming this problem is to leverage the thousands of complete viral genomes that are publicly available. Here we describe our efforts to assemble a comprehensive resource that provides a quantitative snapshot of viral genomic trends - such as gene density, noncoding percentage, and abundances of functional gene categories - across thousands of viral genomes. We have also developed a coarse-grained method for visualizing viral genome organization for hundreds of genomes at once, and have explored the extent of the overlap

SUBMITTER: Mahmoudabadi G 

PROVIDER: S-EPMC5908442 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature