Cardioprotective effect of histamine H2 antagonists in congestive heart failure: A systematic review and meta-analysis.

ABSTRACT:

Background

Histamine H2 antagonists (H2RAs) have long been suggested to have beneficial effects on congestive heart failure (CHF). However, full agreement about the cardioprotective effects of H2RAs is still not reached yet. Therefore, this study aims to clarify the effects of H2RAs on myocardial function in CHF patients by meta-analysis.

Methods

Electronic databases including PubMed, Embase, and Cochrane Library were retrieved. Randomized controlled trials comparing the cardiac effects of H2RAs and placebo or other medicines were collected. Pooled mean differences (MDs) with 95% confidence intervals (CIs) were calculated and meta-analysis was performed using RevMan 5.3 software.

Results

A total of 10 studies (472 participants) were included in this meta-analysis. H2R

SUBMITTER: Zhang J 

PROVIDER: S-EPMC5908598 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature