Identification of genes related to consecutive trauma-induced sepsis via gene expression profiling analysis.

ABSTRACT: We aimed to identify crucial genes relevant to the development of consecutive trauma-induced sepsis.A microarray dataset was used to identify genes differentially expressed between peripheral blood samples from consecutive traumatized patients complicated with sepsis and not complicated with sepsis. The dataset GSE12624 was obtained from Gene Expression Omnibus, containing 34 peripheral blood samples from consecutive traumatized patients complicated by sepsis and 36 consecutive traumatized controls. The differentially expressed genes (DEGs) were identified using Linear Models for Microarray Data package. Then, gene ontology (GO) enrichment analysis for DEGs was performed by Onto-Express. Subsequently, the protein-protein interaction (PPI) network was constructed and pathway enrichment anal

SUBMITTER: Dong L 

PROVIDER: S-EPMC5908625 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature