Oxidation-induced generation of a mild electrophile for proximity-enhanced protein-protein crosslinking.

ABSTRACT: We report a strategy to introduce a reactive electrophile into proteins through the conversion of a chemically inert group into a bioreactive group in response to an inducer molecule. This strategy was demonstrated by oxidation-induced and proximity-enhanced protein-protein crosslinking in the presence of a large excess of free nucleophile.

SUBMITTER: Shang X 

PROVIDER: S-EPMC5908726 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature