Ligand-Doped Copper Oxo-hydroxide Nanoparticles are Effective Antimicrobials.

ABSTRACT: Bacterial resistance to antimicrobial therapies is an increasing clinical problem. This is as true for topical applications as it is for systemic therapy. Topically, copper ions may be effective and cheap antimicrobials that act through multiple pathways thereby limiting opportunities to bacteria for resistance. However, the chemistry of copper does not lend itself to facile formulations that will readily release copper ions at biologically compatible pHs. Here, we have developed nanoparticulate copper hydroxide adipate tartrate (CHAT) as a cheap, safe, and readily synthesised material that should enable antimicrobial copper ion release in an infected wound environment.First, we synthesised CHAT and showed that this had disperse aquated particle sizes of 2-5 nm and a mean zeta potential of

SUBMITTER: Bastos CAP 

PROVIDER: S-EPMC5908776 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature