The Emerging Field of Epitranscriptomics in Neurodevelopmental and Neuronal Disorders.

ABSTRACT: Analogous to DNA methylation and histone modifications, RNA modifications represent a novel layer of regulation of gene expression. The dynamic nature and increasing number of RNA modifications offer new possibilities to rapidly alter gene expression upon specific environmental changes. Recent lines of evidence indicate that modified RNA molecules and associated complexes regulating and "reading" RNA modifications play key roles in the nervous system of several organisms, controlling both, its development and function. Mutations in several human genes that modify transfer RNA (tRNA) have been linked to neurological disorders, in particular to intellectual disability. Loss of RNA modifications alters the stability of tRNA, resulting in reduced translation efficiency and generation of tRNA f

SUBMITTER: Angelova MT 

PROVIDER: S-EPMC5908907 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature