Effectiveness of progestogens to improve perinatal outcome in twin pregnancies: an individual participant data meta-analysis.

ABSTRACT:

Background

In twin pregnancies, the rates of adverse perinatal outcome and subsequent long-term morbidity are substantial, and mainly result from preterm birth (PTB).

Objectives

To assess the effectiveness of progestogen treatment in the prevention of neonatal morbidity or PTB in twin pregnancies using individual participant data meta-analysis (IPDMA).

Search strategy

We searched international scientific databases, trial registration websites, and references of identified articles.

Selection criteria

Randomised clinical trials (RCTs) of 17-hydroxyprogesterone caproate (17Pc) or vaginally administered natural progesterone, compared with placebo or no treatment.

Data collection and analysis

Investigators of identified RCTs were asked to share their IPD. Th

SUBMITTER: Schuit E 

PROVIDER: S-EPMC5909188 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature