Prognostic factors of radiation dermatitis following passive-scattering proton therapy for breast cancer.

ABSTRACT:

Background

To identify prognostic factors for grade 3 radiation dermatitis following passive-scattering proton therapy for breast cancer.

Methods

This retrospective study included data on 23 (11 post-mastectomy and 12 post-lumpectomy) breast cancer patients who underwent proton therapy with the passive scattering technique in our institute from 2012 to 2016. Each patient received 50-50.4 cobalt Gy equivalent (CGE) at 1.8 or 2 CGE per daily fraction. Logistic regression analysis was performed to identify prognostic factors for grade 3 skin toxicity. Receiver operating characteristic (ROC) curve analysis and the area under the curve (AUC) were used to evaluate the performance of the models.

Results

43% of the studied patients developed grade 3 radiation dermatitis. The

SUBMITTER: Liang X 

PROVIDER: S-EPMC5909216 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature