ATMAD: robust image analysis for Automatic Tissue MicroArray De-arraying.

ABSTRACT:

Background

Over the last two decades, an innovative technology called Tissue Microarray (TMA), which combines multi-tissue and DNA microarray concepts, has been widely used in the field of histology. It consists of a collection of several (up to 1000 or more) tissue samples that are assembled onto a single support - typically a glass slide - according to a design grid (array) layout, in order to allow multiplex analysis by treating numerous samples under identical and standardized conditions. However, during the TMA manufacturing process, the sample positions can be highly distorted from the design grid due to the imprecision when assembling tissue samples and the deformation of the embedding waxes. Consequently, these distortions may lead to severe errors of (histological) assay r

SUBMITTER: Nguyen HN 

PROVIDER: S-EPMC5909283 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature