Shear wave elastography predicts hepatocellular carcinoma risk in hepatitis C patients after sustained virological response.

ABSTRACT:

Aim

To evaluate the relationship between fibrosis and HCC after sustained virological response (SVR) to treatment for chronic hepatitis C (HCV).

Methods

This single-center study retrospectively evaluated 196 patients who achieved SVR after HCV infection. The associations of risk factors with HCC development after HCV eradication were evaluated using univariate and multivariate Cox proportional hazards regression models.

Results

Among the 196 patients, 8 patients (4.1%) developed HCC after SVR during a median follow-up of 26 months. Multivariate analyses revealed that HCC development was independently associated with age of ≥75 years (risk ratio [RR] = 35.16), α- fetoprotein levels of ≥6 ng/mL (RR = 40.30), and SWE results of ≥11 kPa (RR = 28.71).

Conclusions

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SUBMITTER: Hamada K 

PROVIDER: S-EPMC5909618 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature