Microdevice integrating innate and adaptive immune responses associated with antigen presentation by dendritic cells.

ABSTRACT: Dendritic cells are the principal antigen presenting cells that are responsible for acquiring and transporting antigen from the peripheral tissue to the secondary lymphoid tissue. There they present it to T cells which ultimately initiate an antigen specific immune response. In vivo, the migration of dendritic cells (DCs) and T cell activation are intimately linked. However, ex vivo systems that facilitate integrated evaluation of DC chemotaxis and resulting T cell activation by migrated DCs are lacking. In this work, we have developed a microfabricated platform that integrates DC chemotaxis with T cell activation. The basic design of the microdevice includes two layers of PDMS, with the top layer comprising the chemotaxis compartment and the bottom layer containing a T cell compartment. I

SUBMITTER: Mitra B 

PROVIDER: S-EPMC5909707 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature