Polygenic Risk for Depression Increases Risk of Ischemic Stroke: From the Stroke Genetics Network Study.

ABSTRACT:

Background and purpose

Although depression is a risk factor for stroke in large prospective studies, it is unknown whether these conditions have a shared genetic basis.

Methods

We applied a polygenic risk score (PRS) for major depressive disorder derived from European ancestry analyses by the Psychiatric Genomics Consortium to a genome-wide association study of ischemic stroke in the Stroke Genetics Network of National Institute of Neurological Disorders and Stroke. Included in separate analyses were 12 577 stroke cases and 25 643 controls of European ancestry and 1353 cases and 2383 controls of African ancestry. We examined the association between depression PRS and ischemic stroke overall and with pathogenic subtypes using logistic regression analyses.

Results

The d

SUBMITTER: Wassertheil-Smoller S 

PROVIDER: S-EPMC5909718 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature