DNA methylation mapping identifies gene regulatory effects in patients with systemic lupus erythematosus.

ABSTRACT:

Objectives

Systemic lupus erythematosus (SLE) is a chronic autoimmune condition with heterogeneous presentation and complex aetiology where DNA methylation changes are emerging as a contributing factor. In order to discover novel epigenetic associations and investigate their relationship to genetic risk for SLE, we analysed DNA methylation profiles in a large collection of patients with SLE and healthy individuals.

Methods

DNA extracted from blood from 548 patients with SLE and 587 healthy controls were analysed on the Illumina HumanMethylation 450 k BeadChip, which targets 485 000 CpG sites across the genome. Single nucleotide polymorphism (SNP) genotype data for 196 524 SNPs on the Illumina ImmunoChip from the same individuals were utilised for methylation quantitative tra

SUBMITTER: Imgenberg-Kreuz J 

PROVIDER: S-EPMC5909746 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature