Circular RNA VMA21 protects against intervertebral disc degeneration through targeting miR-200c and X linked inhibitor-of-apoptosis protein.

ABSTRACT:

Objectives

Circular RNAs (circRNAs) have been proven to function as competing endogenous RNAs to interact with microRNAs (miRNAs) and influence the expression of miRNA target mRNAs. In this study, we investigated whether circRNAs could act as competing endogenous RNAs to regulate the pathological process of intervertebral disc degeneration (IVDD).

Methods

The role and mechanism of a circRNA, circVMA21, in IVDD were explored in nucleus pulposus (NP) cells and degenerative NP tissues from patients and rat models. The interaction between circVMA21 and miR-200c as well as the target mRNA, X linked inhibitor-of-apoptosis protein (XIAP), was examined.

Results

The decreased expression of XIAP in the inflammatory cytokines-treated NP cells and the degenerative NP tissues was

SUBMITTER: Cheng X 

PROVIDER: S-EPMC5909753 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature