Neutrophils provide cellular communication between ileum and mesenteric lymph nodes at graft-versus-host disease onset.

ABSTRACT: Conditioning-induced damage of the intestinal tract plays a critical role during the onset of acute graft-versus-host disease (GVHD). Therapeutic interference with these early events of GVHD is difficult, and currently used immunosuppressive drugs mainly target donor T cells. However, not donor T cells but neutrophils reach the sites of tissue injury first, and therefore could be a potential target for GVHD prevention. A detailed analysis of neutrophil fate during acute GVHD and the effect on T cells is difficult because of the short lifespan of this cell type. By using a novel photoconverter reporter system, we show that neutrophils that had been photoconverted in the ileum postconditioning later migrated to mesenteric lymph nodes (mLN). This neutrophil migration was dependent on the inte

SUBMITTER: Hulsdunker J 

PROVIDER: S-EPMC5909763 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature