Targeted Drug Delivery in the Suprachoroidal Space by Swollen Hydrogel Pushing.

ABSTRACT: Purpose:The purpose is to target model drug particles to the posterior region of the suprachoroidal space (SCS) of the eye controlled via pushing by hydrogel swelling. Methods:A particle formulation containing 1% hyaluronic acid (HA) with fluorescent polymer particles and a hydrogel formulation containing 4% HA were introduced in a single syringe as two layers without mixing, and injected sequentially into the SCS of the rabbit eye ex vivo and in vivo using a microneedle. Distribution of particles in the eye was determined by microscopy. Results:During injection, the particle formulation was pushed toward the middle of the SCS by the viscous hydrogel formulation, but less than 12% of particles reached the posterior SCS. After injection, the particle formulation was pushed further toward th

SUBMITTER: Jung JH 

PROVIDER: S-EPMC5909801 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature