¹⁸F-FDOPA PET/MRI for monitoring early response to bevacizumab in children with recurrent brain tumors.

ABSTRACT:

Background

Noninvasively predicting early response to therapy in recurrent pediatric brain tumors provides a challenge. 3,4-dihydroxy-6-[¹⁸F]fluoro-L-phenylalanine (¹⁸F-FDOPA) PET/MRI has not been previously studied as a tool to evaluate early response to antiangiogenic therapy in children. The purpose of this study was to evaluate the safety and feasibility of using ¹⁸F-FDOPA PET/MRI to assess response to bevacizumab in children with relapsed brain tumors.

Materials and methods

Six patients with recurrent gliomas (5 low-grade, 1 high-grade) planned to undergo treatment with bevacizumab were enrolled. ¹⁸F-FDOPA PET/MRI scans were obtained prior to and 4 weeks following the start of treatment, and these were compared with the clinic

SUBMITTER: Gauvain K 

PROVIDER: S-EPMC5909807 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature