Effect of Fecal Microbiota Transplantation on Recurrence in Multiply Recurrent Clostridium difficile Infection: A Randomized Trial.

ABSTRACT:

Background

To date, evidence for the efficacy of fecal microbiota transplantation (FMT) in recurrent Clostridium difficile infection (CDI) has been limited to case series and open-label clinical trials.

Objective

To determine the efficacy and safety of FMT for treatment of recurrent CDI.

Design

Randomized, controlled, double-blind clinical trial. (ClinicalTrials.gov: NCT01703494).

Setting

Two academic medical centers.

Patients

46 patients who had 3 or more recurrences of CDI and received a full course of vancomycin for their most recent acute episode.

Intervention

Fecal microbiota transplantation with donor stool (heterologous) or patient's own stool (autologous) administered by colonoscopy.

Measurements

The primary end point was resolution

SUBMITTER: Kelly CR 

PROVIDER: S-EPMC5909820 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature