Resveratrol protects from lipopolysaccharide-induced inflammation in the uterus and prevents experimental preterm birth.

ABSTRACT:

Study question

Is resveratrol able to prevent the lipopolysaccharide (LPS)-induced preterm labor in 15-day pregnant BALB/c mice?

Summary answer

Resveratrol prevented the LPS-induced onset of preterm labor in 64% of the cases and showed anti-inflammatory and tocolytic effects by downregulating COX-2 and iNOS expression and NOS activity, and by changing the uterine prostaglandin and endocannabinoid profiling.

What is known already

Genital tract infections by Gram-negative bacteria are a common complication in human pregnancy and have been shown to increase risk of preterm delivery. Bacterial LPS elicits a strong maternal inflammatory response that results in preterm delivery and fetal death in a murine model endotoxin-induced preterm labor.

Study design, size, durati

SUBMITTER: Bariani MV 

PROVIDER: S-EPMC5909859 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature