Sweat glucose and GLUT2 expression in atopic dermatitis: Implication for clinical manifestation and treatment.

ABSTRACT: Sweat includes active components and metabolites, which are needed to maintain skin homeostasis. Component changes in sweat derived from atopic dermatitis (AD) have been reported. To investigate the influence of sweat components on the pathogenesis of AD, we performed a multifaceted assessment, including nuclear magnetic resonance spectroscopy-based metabolomic analysis, and linked these features to clinical features of AD. Distinctive properties of AD sweat are the quite-variation in protein, anti-microbial peptides and glucose concentrations. pH, sodium, and other salt levels in sweat of AD were comparable to that of healthy subjects. Sweat from AD patients with acute inflammation had a more prominent increase in glucose concentration than sweat from healthy individuals or those with AD

SUBMITTER: Ono E 

PROVIDER: S-EPMC5909908 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature