Catechol-O-Methyltransferase moderates effect of stress mindset on affect and cognition.

ABSTRACT: There is evidence that altering stress mindset-the belief that stress is enhancing vs. debilitating-can change cognitive, affective and physiological responses to stress. However individual differences in responsiveness to stress mindset manipulations have not been explored. Given the previously established role of catecholamines in both placebo effects and stress, we hypothesized that genetic variation in catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, would moderate responses to an intervention intended to alter participants' mindsets about stress. Participants (N = 107) were exposed to a stress mindset manipulation (videos highlighting either the enhancing or debilitating effects of stress) prior to engaging in a Trier Social Stress task and subsequent co

SUBMITTER: Crum AJ 

PROVIDER: S-EPMC5909917 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature