Quantification of perivascular spaces at 7T: A potential MRI biomarker for epilepsy.

ABSTRACT: PURPOSE:7T (7T) magnetic resonance imaging (MRI) facilitates the visualization of the brain with resolution and contrast beyond what is available at conventional clinical field strengths, enabling improved detection and quantification of small structural features such as perivascular spaces (PVSs). The distribution of PVSs, detected in vivo at 7T, may act as a biomarker for the effects of epilepsy. In this work, we systematically quantify the PVSs in the brains of epilepsy patients and compare them to healthy controls. METHODS:T2-weighted turbo spin echo images were obtained at 7T on 21 epilepsy patients and 17 healthy controls. For all subjects, PVSs were manually marked on Osirix image analysis software. Marked PVSs with diameter≥0.5mm were then mapped by hemisphere and lobe. The asymmet

SUBMITTER: Feldman RE 

PROVIDER: S-EPMC5909959 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature