Circulating miRNA Profiles Associated With Hyperglycemia in Patients With Type 1 Diabetes.

ABSTRACT: We investigated plasma microRNA (miRNA) profiles associated with variation of hyperglycemia, measured as hemoglobin A_1c (HbA_1c), in two panels of patients with type 1 diabetes (T1D). Using the HTG Molecular Diagnostics EdgeSeq platform, 2,083 miRNAs were measured in plasma from 71 patients included in a screening panel. Quantitative real-time PCR was used to measure the candidate miRNAs in plasma from 95 patients included in an independent replication panel. We found 10 miRNAs replicated in both panels and 4 with high statistical significance. The strongest positive correlations with HbA_1c were found with miR-125b-5p (r_s = 0.40, P = 6.0 × 10^-5) and miR-365a-3p (r_s = 0.35, P = 5.9 × 10^-4

SUBMITTER: Satake E 

PROVIDER: S-EPMC5910001 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature