Functional Heterogeneity of Endothelial Cells Derived from Human Pluripotent Stem Cells.

ABSTRACT: Specification of endothelial cells (ECs) into arterial, venous, and lymphatic cells is a crucial process of vascular development, and expanding our knowledge about EC specification from human pluripotent stem cells (hPSCs) will aid the design of optimal strategies for producing desired types of ECs for therapies. In our prior studies, we revealed that hPSC-derived VE-cadherin(V)⁺CD31⁺CD34⁺ ECs are heterogeneous and include at least three major subsets with distinct hemogenic properties: V⁺CD43/235a^-CD73^- hemogenic endothelial progenitors (HEPs), V⁺CD43^loCD235a⁺73^- angiogenic hematopoietic progenitors (AHPs), and V⁺CD43/235a^-73⁺ non-HEPs. In this stu

SUBMITTER: D'Souza SS 

PROVIDER: S-EPMC5910050 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature