Suberanilohydroxamic acid prevents TGF-β1-induced COX-2 repression in human lung fibroblasts post-transcriptionally by TIA-1 downregulation.

ABSTRACT: Cyclooxygenase-2 (COX-2), with its main antifibrotic metabolite PGE₂, is regarded as an antifibrotic gene. Repressed COX-2 expression and deficient PGE₂ have been shown to contribute to the activation of lung fibroblasts and excessive deposition of collagen in pulmonary fibrosis. We have previously demonstrated that COX-2 expression in lung fibroblasts from patients with idiopathic pulmonary fibrosis (IPF) is epigenetically silenced and can be restored by epigenetic inhibitors. This study aimed to investigate whether COX-2 downregulation induced by the profibrotic cytokine transforming growth factor-β1 (TGF-β1) in normal lung fibroblasts could be prevented by epigenetic inhibitors. We found that COX-2 protein expression and PGE₂ production were markedly red

SUBMITTER: Pasini A 

PROVIDER: S-EPMC5910054 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature