Spontaneous activity forms a foundation for odor-evoked activation maps in the rat olfactory bulb.

ABSTRACT: Fluctuations in spontaneous activity have been observed by many neuroimaging techniques, but because these resting-state changes are not evoked by stimuli, it is difficult to determine how they relate to task-evoked activations. We conducted multi-modal neuroimaging scans of the rat olfactory bulb, both with and without odor, to examine interaction between spontaneous and evoked activities. Independent component analysis of spontaneous fluctuations revealed resting-state networks, and odor-evoked changes revealed activation maps. We constructed simulated activation maps using resting-state networks that were highly correlated to evoked activation maps. Simulated activation maps derived by intrinsic optical signal (IOS), which covers the dorsal portion of the glomerular sheet, significantly

SUBMITTER: Thompson GJ 

PROVIDER: S-EPMC5910178 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature