Quantifying axonal responses in patient-specific models of subthalamic deep brain stimulation.

ABSTRACT: Medical imaging has played a major role in defining the general anatomical targets for deep brain stimulation (DBS) therapies. However, specifics on the underlying brain circuitry that is directly modulated by DBS electric fields remain relatively undefined. Detailed biophysical modeling of DBS provides an approach to quantify the theoretical responses to stimulation at the cellular level, and has established a key role for axonal activation in the therapeutic mechanisms of DBS. Estimates of DBS-induced axonal activation can then be coupled with advances in defining the structural connectome of the human brain to provide insight into the modulated brain circuitry and possible correlations with clinical outcomes. These pathway-activation models (PAMs) represent powerful tools for DBS resear

SUBMITTER: Gunalan K 

PROVIDER: S-EPMC5910209 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature