Volumetric segmentation-free method for rapid visualization of vascular wall shear stress using 4D flow MRI.

ABSTRACT:

Purpose

To develop a rapid segmentation-free method to visualize and compute wall shear stress (WSS) throughout the aorta using 4D Flow MRI data. WSS is the drag force-per-area the vessel endothelium exerts on luminal blood; abnormal levels of WSS are associated with cardiovascular pathologies. Previous methods for computing WSS are bottlenecked by labor-intensive manual segmentation of vessel boundaries. A rapid automated segmentation-free method for computing WSS is presented.

Theory and methods

Shear stress is the dot-product of the viscous stress tensor and the inward normal vector. The inward normal vectors are approximated as the gradient of fluid speed at every voxel. Subsequently, a 4D map of shear stress is computed as the partial derivatives of velocity with respec

SUBMITTER: Masutani EM 

PROVIDER: S-EPMC5910222 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature