Simultaneous editing of GABA and glutathione at 7T using semi-LASER localization.

ABSTRACT:

Purpose

To demonstrate simultaneous editing of the two most commonly edited and overlapping signals, γ-aminobutyric acid (GABA), and glutathione (GSH), with Hadamard encoding and reconstruction of MEGA-edited spectroscopy (HERMES) using sLASER localization at 7T.

Methods

Density matrix simulations of HERMES at 7T were carried out and compared with phantom experiments. Additional phantom experiments were performed to characterize the echo time (TE) -dependent modulation of GABA- and GSH-edited HERMES spectra at TE of 80-160 ms. In vivo experiments were performed in 10 healthy volunteers, comparing HERMES (11 min) to sequentially acquired MEGA-sLASER detection of GABA and GSH (2 × 11 min).

Results

Simulations of HERMES show GABA- and GSH-edited spectra with negligible l

SUBMITTER: Saleh MG 

PROVIDER: S-EPMC5910225 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature