Development of subcortical volumes across adolescence in males and females: A multisample study of longitudinal changes.

ABSTRACT: The developmental patterns of subcortical brain volumes in males and females observed in previous studies have been inconsistent. To help resolve these discrepancies, we examined developmental trajectories using three independent longitudinal samples of participants in the age-span of 8-22 years (total 216 participants and 467 scans). These datasets, including Pittsburgh (PIT; University of Pittsburgh, USA), NeuroCognitive Development (NCD; University of Oslo, Norway), and Orygen Adolescent Development Study (OADS; The University of Melbourne, Australia), span three countries and were analyzed together and in parallel using mixed-effects modeling with both generalized additive models and general linear models. For all regions and across all samples, males were found to have significantly l

SUBMITTER: Herting MM 

PROVIDER: S-EPMC5910239 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature