Natural history and clinical detection of undiagnosed coeliac disease in a North American community.

ABSTRACT:

Background

Coeliac disease is a substantially underdiagnosed disorder, with clinical testing currently guided by case finding.

Aim

To determine the presence of indications for diagnostic testing and frequency of clinical testing in undiagnosed coeliac disease.

Methods

This was a case-control study of adults without prior diagnosis of coeliac disease. Undiagnosed cases were identified through sequential serology, and unaffected age- and gender-matched controls were selected. Medical records were systematically reviewed for indications for and evidence of clinical testing.

Results

Of 47 557 adults, 408 cases of undiagnosed coeliac disease were identified. 408 serology negative matched controls were selected. Eight-matched pairs were excluded, leading to 800 inclu

SUBMITTER: Hujoel IA 

PROVIDER: S-EPMC5910260 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature