Simple and robust referencing system enables identification of dissolved-phase xenon spectral frequencies.

ABSTRACT:

Purpose

To assess the effect of macroscopic susceptibility gradients on the gas-phase referenced dissolved-phase ¹²⁹ Xe (DPXe) chemical shift (CS) and to establish the robustness of a water-based referencing system for in vivo DPXe spectra.

Methods

Frequency shifts induced by spatially varying magnetic susceptibility are calculated by finite-element analysis for the human head and chest. Their effect on traditional gas-phase referenced DPXe CS is then assessed theoretically and experimentally. A water-based referencing system for the DPXe resonances that uses the local water protons as reference is proposed and demonstrated in vivo in rats.

Results

Across the human brain, macroscopic susceptibility gradients can induce an apparent variation in the DPXe CS o

SUBMITTER: Antonacci MA 

PROVIDER: S-EPMC5910273 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature