Quantitative trait locus mapping and analysis of heritable variation in affiliative social behavior and co-occurring traits.

ABSTRACT: Humans exhibit broad heterogeneity in affiliative social behavior. Twin and family studies show that individual differences in core dimensions of social behavior are heritable, yet there are knowledge gaps in understanding the underlying genetic and neurobiological mechanisms. Animal genetic reference panels (GRPs) provide a tractable strategy for examining the behavioral and genetic architecture of complex traits. Here, using males from 50 mouse strains from the BXD GRP, 4 domains of affiliative social behavior-social approach, social recognition, direct social interaction (DSI) (partner sniffing) and vocal communication-were examined in 2 widely used behavioral tasks-the 3-chamber and DSI tasks. There was continuous and broad variation in social and nonsocial traits, with moderate to hig

SUBMITTER: Knoll AT 

PROVIDER: S-EPMC5910301 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature