Short versus long duration of dual antiplatelet therapy following drug-eluting stents: a meta-analysis of randomised trials.

ABSTRACT: BACKGROUND:Dual antiplatelet therapy (DAPT) remains the cornerstone therapy in the prevention of ischaemic events following drug-eluting stent (DES) implantation. Mandatory duration of DAPT after DES however, is a matter of debate. We aimed to evaluate safety and efficacy of short-term (up to 6 months) versus long-term (12 months) DAPT after DES implantation. METHODS:We searched PubMed, EMBASE, Cochrane databases, and international meetings for randomised clinical trials (RCTs) comparing short with long DAPT. We performed a systematic review and meta-analysis of major trials with primary outcomes: all-cause death, myocardial infarction, definite or probable stent thrombosis, stroke, and major bleeding event. RESULTS:Nine RCTs with a total number of 19,099 patients were pooled in the presen

SUBMITTER: Rozemeijer R 

PROVIDER: S-EPMC5910311 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature