Mechanisms of curcumin-induced gastroprotection against ethanol-induced gastric mucosal lesions.

ABSTRACT:

Background

Curcumin, a pleiotropic substance used for centuries in traditional medicine, exhibits antioxidant, anti-inflammatory and antiproliferative efficacy against various tumours, but the role of curcumin in gastroprotection is little studied. We determined the effect of curcumin against gastric haemorrhagic lesions induced by 75% ethanol and alterations in gastric blood flow (GBF) in rats with cyclooxygenase-1 (COX-1) and COX-2 activity inhibited by indomethacin, SC-560 or rofecoxib, inhibited NO-synthase activity, capsaicin denervation and blockade of TRPV1 receptors by capsazepine.

Methods

One hour after ethanol administration, the gastric mucosal lesions were assessed by planimetry, the GBF was examined by H₂ gas clearance, plasma gastrin was determined b

SUBMITTER: Czekaj R 

PROVIDER: S-EPMC5910495 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature