Prenatal and early-life diesel exhaust exposure causes autism-like behavioral changes in mice.

ABSTRACT:

Background

Escalating prevalence of autism spectrum disorders (ASD) in recent decades has triggered increasing efforts in understanding roles played by environmental risk factors as a way to address this widespread public health concern. Several epidemiological studies show associations between developmental exposure to traffic-related air pollution and increased ASD risk. In rodent models, a limited number of studies have shown that developmental exposure to ambient ultrafine particulates or diesel exhaust (DE) can result in behavioral phenotypes consistent with mild ASD. We performed a series of experiments to determine whether developmental DE exposure induces ASD-related behaviors in mice.

Results

C57Bl/6J mice were exposed from embryonic day 0 to postnatal day 21 to 250

SUBMITTER: Chang YC 

PROVIDER: S-EPMC5910592 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature