Dramatic pressure-sensitive ion conduction in conical nanopores.

ABSTRACT: Ion transporters in Nature exhibit a wealth of complex transport properties such as voltage gating, activation, and mechanosensitive behavior. When combined, such processes result in advanced ionic machines achieving active ion transport, high selectivity, or signal processing. On the artificial side, there has been much recent progress in the design and study of transport in ionic channels, but mimicking the advanced functionalities of ion transporters remains as yet out of reach. A prerequisite is the development of ionic responses sensitive to external stimuli. In the present work, we report a counterintuitive and highly nonlinear coupling between electric and pressure-driven transport in a conical nanopore, manifesting as a strong pressure dependence of the ionic conductance. This resu

SUBMITTER: Jubin L 

PROVIDER: S-EPMC5910861 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature