Nephrin as a biomarker of sickle cell glomerulopathy in Malawi.

ABSTRACT:

Background

Glomerulopathy is an increasingly identified complication in young patients with sickle cell disease (SCD). Hyperfiltration and albuminuria followed by declining glomerular filtration rates and eventual end-stage renal disease (ESRD) is assumed to be the typical progression of glomerular disease. There are only a few reported biomarkers to identify early-stage renal disease in SCD.

Procedures

We detail the renal profile of 101 children with SCD in Malawi and propose a novel urinary biomarker for the identification of early renal disease.

Results

Among children with sickle cell anemia, 24.8% had a urine albumin-creatinine ratio of 30 mg/g or above. In univariate analysis, only patients with higher urinary nephrin, a urinary marker of glomerular injury, had s

SUBMITTER: Heimlich JB 

PROVIDER: S-EPMC5911184 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature