A cross-sectional study of general cognitive abilities among Uruguayan school children with low-level arsenic exposure, potential effect modification by methylation capacity and dietary folate.

ABSTRACT:

Background

Few studies have evaluated the association between low-level arsenic (As) exposure and cognitive performance among children.

Objectives

In this cross-sectional study, we assessed the association between low-level As exposure and cognitive performance among 5-8 year-old children in Montevideo, and tested effect modification by As methylation capacity and children's dietary folate intake.

Methods

We measured total urinary As (UAs) concentrations and the proportion of monomethylarsonic acid (MMA) in the urine of 328 children. Seven subtests of the standardized Woodcock-Muñoz cognitive battery were used to assess cognitive performance, from which, the general intellectual abilities (GIA) score was derived. Total folate intake was estimated from two 24-h dietary

SUBMITTER: Desai G 

PROVIDER: S-EPMC5911190 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature