In Silico Characterization and Structural Modeling of Dermacentor andersoni p36 Immunosuppressive Protein.

ABSTRACT: Ticks cause approximately $17-19 billion economic losses to the livestock industry globally. Development of recombinant antitick vaccine is greatly hindered by insufficient knowledge and understanding of proteins expressed by ticks. Ticks secrete immunosuppressant proteins that modulate the host's immune system during blood feeding; these molecules could be a target for antivector vaccine development. Recombinant p36, a 36 kDa immunosuppressor from the saliva of female Dermacentor andersoni, suppresses T-lymphocytes proliferation in vitro. To identify potential unique structural and dynamic properties responsible for the immunosuppressive function of p36 proteins, this study utilized bioinformatic tool to characterize and model structure of D. andersoni p36 protein. Ev

SUBMITTER: Oyugi MO 

PROVIDER: S-EPMC5911333 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature