The genetic epidemiology of substance use disorder: A review.

ABSTRACT:

Background

Substance use disorder (SUD) remains a significant public health issue. A greater understanding of how genes and environment interact to regulate phenotypes comprising SUD will facilitate directed treatments and prevention.

Methods

The literature studying the neurobiological correlates of SUD with a focus on the genetic and environmental influences underlying these mechanisms was reviewed. Results from twin/family, human genetic association, gene-environment interaction, epigenetic literature, phenome-wide association studies are summarized for alcohol, nicotine, cannabinoids, cocaine, and opioids.

Results

There are substantial genetic influences on SUD that are expected to influence multiple neurotransmission pathways, and these influences are particularly

SUBMITTER: Prom-Wormley EC 

PROVIDER: S-EPMC5911369 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature