Comparative genomics analysis of Clostridium difficile epidemic strain DH/NAP11/106.

ABSTRACT: Clostridium difficile PCR ribotype 106 (also identified as restriction endonuclease analysis [REA] group DH) recently emerged as the most common strain causing C. difficile infection (CDI) among US adults. We previously identified this strain predominating our pediatric cohort. Pediatric clinical CDI isolates previously characterized by REA underwent antibiotic resistance testing and whole genome sequencing. Of 134 isolates collected from children, 31 (23%) were REA group DH. We performed a comparative genomics analysis to identify DH-associated accessory genes. We identified five DH-associated genes that are associated with virulence in other bacterial species but not previously known to contribute to CDI. These genes are associated with intestinal mucosal adhesion (collagen-binding surfa

SUBMITTER: Kociolek LK 

PROVIDER: S-EPMC5911408 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature