Metabolic modeling helps interpret transcriptomic changes during malaria.

ABSTRACT: Disease represents a specific case of malfunctioning within a complex system. Whereas it is often feasible to observe and possibly treat the symptoms of a disease, it is much more challenging to identify and characterize its molecular root causes. Even in infectious diseases that are caused by a known parasite, it is often impossible to pinpoint exactly which molecular profiles of components or processes are directly or indirectly altered. However, a deep understanding of such profiles is a prerequisite for rational, efficacious treatments. Modern omics methodologies are permitting large-scale scans of some molecular profiles, but these scans often yield results that are not intuitive and difficult to interpret. For instance, the comparison of healthy and diseased transcriptome profiles ma

SUBMITTER: Tang Y 

PROVIDER: S-EPMC5911422 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature