Treatment of rheumatoid arthritis with biologic agents lowers the risk of incident chronic kidney disease.

ABSTRACT: Rheumatoid arthritis is associated with reduced kidney function, possibly due to chronic inflammation or the use of nephrotoxic therapies. However, little is known about the effects of using the newer novel non-nephrotoxic biologic agents on the risk of incident chronic kidney disease (CKD). To study this we used a cohort of 20,757 United States veterans diagnosed with rheumatoid arthritis with an estimated glomerular filtration rate (eGFR) of 60 mL/min/1.73m² or more, recruited between October 2004 and September 2006, and followed through 2013. The associations of biologic use with incident CKD (eGFR under 60 with a decrease of at least 25% from baseline, and eGFR under 45 mL/min/1.73m²) and change in eGFR (<-3, -3 to <0 [reference], and ≥0 mL/min/1.73m²/y

SUBMITTER: Sumida K 

PROVIDER: S-EPMC5911428 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature