Theta-Gamma Coupling and Working Memory in Alzheimer's Dementia and Mild Cognitive Impairment.

ABSTRACT: Working memory deficits are common among individuals with Alzheimer's dementia (AD) or mild cognitive impairment (MCI). Yet, little is known about the mechanisms underlying these deficits. Theta-gamma coupling-the modulation of high-frequency gamma oscillations by low-frequency theta oscillations-is a neurophysiologic process underlying working memory. We assessed the relationship between theta-gamma coupling and working memory deficits in AD and MCI. We hypothesized that: (1) individuals with AD would display the most significant working memory impairments followed by MCI and finally healthy control (HC) participants; and (2) there would be a significant association between working memory performance and theta-gamma coupling across all participants. Ninety-eight participants completed the

SUBMITTER: Goodman MS 

PROVIDER: S-EPMC5911490 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature