Investigation into the cellular origins of posterior regeneration in the annelid Capitella teleta.

ABSTRACT: Many animals can regenerate, although there is great diversity in regenerative capabilities. A major question in regenerative biology is determining the cellular source of newly formed tissue. The polychaete annelid, Capitella teleta, can regenerate posterior segments following transverse amputation. However, the source, behavior and molecular characteristics of the cells that form new tissue during regeneration are largely unknown. Using an indirect cell tracking method involving 5'-ethynyl-2'-deoxyuridine (EdU) incorporation, we show that cell migration occurs during C. teleta posterior regeneration. Expression of the multipotency/germ line marker CapI-vasa led us to hypothesize that stem cells originate from a multipotent progenitor cell (MPC) cluster, migrate throu

SUBMITTER: de Jong DM 

PROVIDER: S-EPMC5911572 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature